Influence of solubilization and AD-mutations on stability and structure of human presenilins

Presenilin (PS1 or PS2) functions as the catalytic subunit of γ-secretase, which produces the toxic amyloid beta peptides in Alzheimer’s disease (AD). The dependence of folding and structural stability of PSs on the lipophilic environment and mutation were investigated by far UV CD spectroscopy. The...

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Detalles Bibliográficos
Autores principales: Yang, Ge, Yu, Kun, Kaitatzi, Christina-Symina, Singh, Abhilasha, Labahn, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740079/
https://www.ncbi.nlm.nih.gov/pubmed/29269939
http://dx.doi.org/10.1038/s41598-017-18313-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740079/
https://www.ncbi.nlm.nih.gov/pubmed/29269939
http://dx.doi.org/10.1038/s41598-017-18313-x

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