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Generation of therapeutic protein variants with the human serum albumin binding capacity via site-specific fatty acid conjugation
Extension of the serum half-life is an important issue in developing new therapeutic proteins and expanding applications of existing therapeutic proteins. Conjugation of fatty acid, a natural human serum albumin ligand, to a therapeutic protein/peptide was developed as a technique to extend the seru...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740134/ https://www.ncbi.nlm.nih.gov/pubmed/29269881 http://dx.doi.org/10.1038/s41598-017-18029-y |