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Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not secrete glutamate. Indeed, low...
Autores principales: | Dornier, Emmanuel, Rabas, Nicolas, Mitchell, Louise, Novo, David, Dhayade, Sandeep, Marco, Sergi, Mackay, Gillian, Sumpton, David, Pallares, Maria, Nixon, Colin, Blyth, Karen, Macpherson, Iain R., Rainero, Elena, Norman, Jim C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740148/ https://www.ncbi.nlm.nih.gov/pubmed/29269878 http://dx.doi.org/10.1038/s41467-017-02101-2 |
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