Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

Liver metabolism undergoes robust circadian oscillations in gene expression and enzymatic activity essential for liver homeostasis, but whether the circadian clock controls homeostatic self-renewal of hepatocytes is unknown. Here we show that hepatocyte polyploidization is markedly accelerated aroun...

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Detalles Bibliográficos
Autores principales: Chao, Hsu-Wen, Doi, Masao, Fustin, Jean-Michel, Chen, Huatao, Murase, Kimihiko, Maeda, Yuki, Hayashi, Hida, Tanaka, Rina, Sugawa, Maho, Mizukuchi, Naoki, Yamaguchi, Yoshiaki, Yasunaga, Jun-ichirou, Matsuoka, Masao, Sakai, Mashito, Matsumoto, Michihiro, Hamada, Shinshichi, Okamura, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740157/
https://www.ncbi.nlm.nih.gov/pubmed/29269828
http://dx.doi.org/10.1038/s41467-017-02207-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740157/
https://www.ncbi.nlm.nih.gov/pubmed/29269828
http://dx.doi.org/10.1038/s41467-017-02207-7

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