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Minocycline protects against delayed cerebral ischemia after subarachnoid hemorrhage via matrix metalloproteinase‐9 inhibition

OBJECTIVE: Delayed cerebral ischemia (DCI) is an independent risk factor for poor outcome after aneurysmal subarachnoid hemorrhage (SAH) and is multifactorial in etiology. While prior studies have suggested a role for matrix metalloproteinase‐9 (MMP‐9) in early brain injury after SAH, its contributi...

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Detalles Bibliográficos
Autores principales: Vellimana, Ananth K., Zhou, Meng‐Liang, Singh, Itender, Aum, Diane J., Nelson, James W., Harris, Glenn R., Athiraman, Umeshkumar, Han, Byung H., Zipfel, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740245/
https://www.ncbi.nlm.nih.gov/pubmed/29296615
http://dx.doi.org/10.1002/acn3.492