Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods

BACKGROUND: Thiopurine S-methyltransferase (TPMT) enzyme metabolizes thiopurine drugs which are widely used in various disciplines as well as in leukemias. Individual enzyme activity varies depending on the genetic polymorphisms of TPMT gene located at chromosome 6. Up to 14% of popu-lation is known...

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Detalles Bibliográficos
Autores principales: Asadov, Chingiz, Aliyeva, Gunay, Mustafayeva, Kamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740490/
https://www.ncbi.nlm.nih.gov/pubmed/28552060
http://dx.doi.org/10.2174/1871525715666170529091921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740490/
https://www.ncbi.nlm.nih.gov/pubmed/28552060
http://dx.doi.org/10.2174/1871525715666170529091921

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