CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease that affects the cartilage, synovium, and subchondral bone and is the leading cause of disability in older populations. Specific diagnostic biomarkers are lacking; hence, treatment options for OA are limited. Synovial inflammation is ve...

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Detalles Bibliográficos
Autores principales: Hou, Sheng-Mou, Hou, Chun-Han, Liu, Ju-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740560/
https://www.ncbi.nlm.nih.gov/pubmed/29268768
http://dx.doi.org/10.1186/s13075-017-1487-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740560/
https://www.ncbi.nlm.nih.gov/pubmed/29268768
http://dx.doi.org/10.1186/s13075-017-1487-6

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