Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks

The RNA-guided DNA endonuclease Cas9 has emerged as a powerful tool for genome engineering. Cas9 creates targeted double-stranded breaks (DSBs) in the genome. Knockin of specific mutations (precision genome editing) requires homology-directed repair (HDR) of the DSB by synthetic donor DNAs containin...

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Detalles Bibliográficos
Autores principales: Paix, Alexandre, Folkmann, Andrew, Goldman, Daniel H., Kulaga, Heather, Grzelak, Michael J., Rasoloson, Dominique, Paidemarry, Supriya, Green, Rachel, Reed, Randall R., Seydoux, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740635/
https://www.ncbi.nlm.nih.gov/pubmed/29183983
http://dx.doi.org/10.1073/pnas.1711979114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740635/
https://www.ncbi.nlm.nih.gov/pubmed/29183983
http://dx.doi.org/10.1073/pnas.1711979114

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