Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)

Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach generally suffers from low consistency between screens. We found that many SS/L interactions involve essential genes and are therefore detectabl...

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Detalles Bibliográficos
Autores principales: Housden, Benjamin E., Li, Zhongchi, Kelley, Colleen, Wang, Yuanli, Hu, Yanhui, Valvezan, Alexander J., Manning, Brendan D., Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740648/
https://www.ncbi.nlm.nih.gov/pubmed/29183982
http://dx.doi.org/10.1073/pnas.1713362114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740648/
https://www.ncbi.nlm.nih.gov/pubmed/29183982
http://dx.doi.org/10.1073/pnas.1713362114

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