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Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA)
Synthetic sick or synthetic lethal (SS/L) screens are a powerful way to identify candidate drug targets to specifically kill tumor cells, but this approach generally suffers from low consistency between screens. We found that many SS/L interactions involve essential genes and are therefore detectabl...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740648/ https://www.ncbi.nlm.nih.gov/pubmed/29183982 http://dx.doi.org/10.1073/pnas.1713362114 |