Chenodeoxycholic acid attenuates high-fat diet-induced obesity and hyperglycemia via the G protein-coupled bile acid receptor 1 and proliferator-activated receptor γ pathway

G protein-coupled bile acid receptor 1 (TGR5) serves a key function in regulating glycometabolism. TGR5 is highly expressed in the mitochondria of brown adipose tissue (BAT) and downregulates adenosine triphosphate synthesis via the bile acid-TGR5-cyclic adenosine monophosphate-2-iodothyronine deiod...

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Detalles Bibliográficos
Autores principales: Chen, Xiaosong, Yan, Liu, Guo, Zhihui, Chen, Ying, Li, Ming, Huang, Chushan, Chen, Zhaohong, Meng, Xiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740767/
https://www.ncbi.nlm.nih.gov/pubmed/29285057
http://dx.doi.org/10.3892/etm.2017.5232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740767/
https://www.ncbi.nlm.nih.gov/pubmed/29285057
http://dx.doi.org/10.3892/etm.2017.5232

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