Deep learning of the regulatory grammar of yeast 5′ untranslated regions from 500,000 random sequences

Our ability to predict protein expression from DNA sequence alone remains poor, reflecting our limited understanding of cis-regulatory grammar and hampering the design of engineered genes for synthetic biology applications. Here, we generate a model that predicts the protein expression of the 5′ unt...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuperus, Josh T., Groves, Benjamin, Kuchina, Anna, Rosenberg, Alexander B., Jojic, Nebojsa, Fields, Stanley, Seelig, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741052/
https://www.ncbi.nlm.nih.gov/pubmed/29097404
http://dx.doi.org/10.1101/gr.224964.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741052/
https://www.ncbi.nlm.nih.gov/pubmed/29097404
http://dx.doi.org/10.1101/gr.224964.117

Ejemplares similares