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Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa

PURPOSE: The apoptotic mechanisms responsible for secondary cone death in retinitis pigmentosa (RP) remain largely unknown. The cone-enriched apoptotic protease caspase-7 (Casp7) is thought to be triggered by endoplasmic reticulum (ER) stress and plays a pivotal role in mice deficient in the cone cy...

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Detalles Bibliográficos
Autores principales: Venkatesh, Aditya, Cheng, Shun-Yun, Punzo, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741377/
https://www.ncbi.nlm.nih.gov/pubmed/29296074