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The opposing forces of shear flow and sphingosine-1-phosphate control marginal zone B cell shuttling

Splenic marginal zone B cells (MZB) shuttle between the blood-filled marginal zone for antigen collection and the follicle for antigen delivery. However, it is unclear how MZBs migrate directionally from the marginal zone to the follicle. Here, we show that murine MZBs migrate up shear flow via the...

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Detalles Bibliográficos
Autores principales: Tedford, Kerry, Steiner, Michael, Koshutin, Stanislav, Richter, Karin, Tech, Laura, Eggers, Yannik, Jansing, Inga, Schilling, Kerstin, Hauser, Anja Erika, Korthals, Mark, Fischer, Klaus-Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741619/
https://www.ncbi.nlm.nih.gov/pubmed/29273735
http://dx.doi.org/10.1038/s41467-017-02482-4