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NCOR1 modulates erythroid disorders caused by mutations of thyroid hormone receptor α1
Thyroid hormone receptor α (THRA) gene mutations, via dominant negative mode, cause erythroid abnormalities in patients. Using mice expressing a dominant negative TRα1 mutant (TRα1PV; Thra1 (PV/+) mice), we showed that TRα1PV acted directly to suppress the expression of key erythroid genes, causing...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741760/ https://www.ncbi.nlm.nih.gov/pubmed/29273766 http://dx.doi.org/10.1038/s41598-017-18409-4 |