Structural determinants for protein unfolding and translocation by the Hsp104 protein disaggregase

The ring-forming Hsp104 ATPase cooperates with Hsp70 and Hsp40 molecular chaperones to rescue stress-damaged proteins from both amorphous and amyloid-forming aggregates. The ability to do so relies upon pore loops present in the first ATP-binding domain (AAA-1; loop-1 and loop-2 ) and in the second...

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Detalles Bibliográficos
Autores principales: Lee, Jungsoon, Sung, Nuri, Yeo, Lythou, Chang, Changsoo, Lee, Sukyeong, Tsai, Francis T.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741831/
https://www.ncbi.nlm.nih.gov/pubmed/29175998
http://dx.doi.org/10.1042/BSR20171399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741831/
https://www.ncbi.nlm.nih.gov/pubmed/29175998
http://dx.doi.org/10.1042/BSR20171399

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