Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice

BACKGROUND: Chemoresistance is a major obstacle that limits the benefits of 5-Fluorouracil (5-Fu)-based chemotherapy for colon cancer patients. Autophagy is an important cellular mechanism underlying chemoresistance. Recent research advances have given new insights into the use of natural bioactive...

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Detalles Bibliográficos
Autores principales: Zhang, Pan, Lai, Ze-Lin, Chen, Hui-Fen, Zhang, Min, Wang, An, Jia, Tao, Sun, Wen-Qin, Zhu, Xi-Min, Chen, Xiao-Feng, Zhao, Zheng, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741949/
https://www.ncbi.nlm.nih.gov/pubmed/29273065
http://dx.doi.org/10.1186/s13046-017-0661-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741949/
https://www.ncbi.nlm.nih.gov/pubmed/29273065
http://dx.doi.org/10.1186/s13046-017-0661-7

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