Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

BACKGROUND: This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male Spragu...

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Detalles Bibliográficos
Autores principales: Forkuo, Arnold Donkor, Ansah, Charles, Pearson, David, Gertsch, Werner, Cirello, Amanda, Amaral, Adam, Spear, Jaimie, Wright, Colin W., Rynn, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741962/
https://www.ncbi.nlm.nih.gov/pubmed/29273084
http://dx.doi.org/10.1186/s40360-017-0188-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741962/
https://www.ncbi.nlm.nih.gov/pubmed/29273084
http://dx.doi.org/10.1186/s40360-017-0188-8

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