TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

The TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine, which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation and transcriptional output are difficult to establish due to challenges of distinguishing global versus locus-specific effects....

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Detalles Bibliográficos
Autores principales: Verma, Nipun, Pan, Heng, Doré, Louis C., Shukla, Abhijit, Li, Qing V., Pelham-Webb, Bobbie, Teijeiro, Virginia, González, Federico, Krivtsov, Andrei, Chang, Chan-Jung, Papapetrou, Eirini P., He, Chuan, Elemento, Olivier, Huangfu, Danwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742051/
https://www.ncbi.nlm.nih.gov/pubmed/29203910
http://dx.doi.org/10.1038/s41588-017-0002-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742051/
https://www.ncbi.nlm.nih.gov/pubmed/29203910
http://dx.doi.org/10.1038/s41588-017-0002-y

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