Annotation-free quantification of RNA splicing using LeafCutter

The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing. LeafCutter identifies variable splicing events from short-read RNA-seq data and finds events of high complexity. Our approach obviates t...

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Detalles Bibliográficos
Autores principales: Li, Yang I, Knowles, David A, Humphrey, Jack, Barbeira, Alvaro N., Dickinson, Scott P., Im, Hae Kyung, Pritchard, Jonathan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742080/
https://www.ncbi.nlm.nih.gov/pubmed/29229983
http://dx.doi.org/10.1038/s41588-017-0004-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742080/
https://www.ncbi.nlm.nih.gov/pubmed/29229983
http://dx.doi.org/10.1038/s41588-017-0004-9

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