Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing's syndrome, metabolic diseases, and delayed wound healing. Aldosterone synthase...

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Detalles Bibliográficos
Autores principales: Akram, Muhammad, Waratchareeyakul, Watcharee, Haupenthal, Joerg, Hartmann, Rolf W., Schuster, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742115/
https://www.ncbi.nlm.nih.gov/pubmed/29312923
http://dx.doi.org/10.3389/fchem.2017.00104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742115/
https://www.ncbi.nlm.nih.gov/pubmed/29312923
http://dx.doi.org/10.3389/fchem.2017.00104

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