Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the bloodstream. A disintegrin and metalloproteinase with...

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Detalles Bibliográficos
Autores principales: Garland, Kathleen S., Reitsma, Stéphanie E., Shirai, Toshiaki, Zilberman-Rudenko, Jevgenia, Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J. T., Puy, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742325/
https://www.ncbi.nlm.nih.gov/pubmed/29326937
http://dx.doi.org/10.3389/fmed.2017.00232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742325/
https://www.ncbi.nlm.nih.gov/pubmed/29326937
http://dx.doi.org/10.3389/fmed.2017.00232

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