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Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions
Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the bloodstream. A disintegrin and metalloproteinase with...
Autores principales: | Garland, Kathleen S., Reitsma, Stéphanie E., Shirai, Toshiaki, Zilberman-Rudenko, Jevgenia, Tucker, Erik I., Gailani, David, Gruber, András, McCarty, Owen J. T., Puy, Cristina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742325/ https://www.ncbi.nlm.nih.gov/pubmed/29326937 http://dx.doi.org/10.3389/fmed.2017.00232 |
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