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Ca(2+) activity signatures of myelin sheath formation and growth in vivo

During myelination, individual oligodendrocytes initially over-produce short myelin sheaths that are either retracted or stabilised. By live imaging oligodendrocyte Ca(2+) activity in vivo, we find that high-amplitude long-duration Ca(2+) transients in sheaths prefigure retractions, mediated by calp...

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Detalles Bibliográficos
Autores principales: Baraban, Marion, Koudelka, Sigrid, Lyons, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742537/
https://www.ncbi.nlm.nih.gov/pubmed/29230058
http://dx.doi.org/10.1038/s41593-017-0040-x