Ca(2+) activity signatures of myelin sheath formation and growth in vivo

During myelination, individual oligodendrocytes initially over-produce short myelin sheaths that are either retracted or stabilised. By live imaging oligodendrocyte Ca(2+) activity in vivo, we find that high-amplitude long-duration Ca(2+) transients in sheaths prefigure retractions, mediated by calp...

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Detalles Bibliográficos
Autores principales: Baraban, Marion, Koudelka, Sigrid, Lyons, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742537/
https://www.ncbi.nlm.nih.gov/pubmed/29230058
http://dx.doi.org/10.1038/s41593-017-0040-x
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author Baraban, Marion
Koudelka, Sigrid
Lyons, David A
author_facet Baraban, Marion
Koudelka, Sigrid
Lyons, David A
author_sort Baraban, Marion
collection PubMed
description During myelination, individual oligodendrocytes initially over-produce short myelin sheaths that are either retracted or stabilised. By live imaging oligodendrocyte Ca(2+) activity in vivo, we find that high-amplitude long-duration Ca(2+) transients in sheaths prefigure retractions, mediated by calpain. Following stabilisation, myelin sheaths grow along axons, and we find that higher frequency Ca(2+) transient activity in sheaths precedes faster elongation. Our data implicate local Ca(2+) signalling in regulating distinct stages of myelination.
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spelling pubmed-57425372018-06-11 Ca(2+) activity signatures of myelin sheath formation and growth in vivo Baraban, Marion Koudelka, Sigrid Lyons, David A Nat Neurosci Article During myelination, individual oligodendrocytes initially over-produce short myelin sheaths that are either retracted or stabilised. By live imaging oligodendrocyte Ca(2+) activity in vivo, we find that high-amplitude long-duration Ca(2+) transients in sheaths prefigure retractions, mediated by calpain. Following stabilisation, myelin sheaths grow along axons, and we find that higher frequency Ca(2+) transient activity in sheaths precedes faster elongation. Our data implicate local Ca(2+) signalling in regulating distinct stages of myelination. 2017-12-11 2018-01 /pmc/articles/PMC5742537/ /pubmed/29230058 http://dx.doi.org/10.1038/s41593-017-0040-x Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Baraban, Marion
Koudelka, Sigrid
Lyons, David A
Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title_full Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title_fullStr Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title_full_unstemmed Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title_short Ca(2+) activity signatures of myelin sheath formation and growth in vivo
title_sort ca(2+) activity signatures of myelin sheath formation and growth in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742537/
https://www.ncbi.nlm.nih.gov/pubmed/29230058
http://dx.doi.org/10.1038/s41593-017-0040-x
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