Synaptotagmin-1 drives synchronous Ca(2+) triggered fusion by C(2)B domain-mediated synaptic vesicle-membrane attachment

The synaptic vesicle (SV) protein Synaptotagmin-1 (Syt1) is the Ca(2+) sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but how these interactions translate into SV fusion remains poorly understood. Utilizing flash...

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Detalles Bibliográficos
Autores principales: Chang, Shuwen, Trimbuch, Thorsten, Rosenmund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742540/
https://www.ncbi.nlm.nih.gov/pubmed/29230057
http://dx.doi.org/10.1038/s41593-017-0037-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742540/
https://www.ncbi.nlm.nih.gov/pubmed/29230057
http://dx.doi.org/10.1038/s41593-017-0037-5

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