Cargando…

Synaptotagmin-1 drives synchronous Ca(2+) triggered fusion by C(2)B domain-mediated synaptic vesicle-membrane attachment

The synaptic vesicle (SV) protein Synaptotagmin-1 (Syt1) is the Ca(2+) sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but how these interactions translate into SV fusion remains poorly understood. Utilizing flash...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Shuwen, Trimbuch, Thorsten, Rosenmund, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742540/ https://www.ncbi.nlm.nih.gov/pubmed/29230057 http://dx.doi.org/10.1038/s41593-017-0037-5

Ejemplares similares

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca(2+)-triggered vesicle fusion
por: Vrljic, Marija, et al.
Publicado: (2010)

Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses
por: Herman, Melissa A., et al.
Publicado: (2018)

Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming
por: Camacho, Marcial, et al.
Publicado: (2017)

Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release
por: Bouazza-Arostegui, Boris, et al.
Publicado: (2022)

Synaptic vesicle fusion
por: Rizo, Josep, et al.
Publicado: (2008)

Synaptotagmin 7 functions as a Ca(2+)-sensor for synaptic vesicle replenishment
por: Liu, Huisheng, et al.
Publicado: (2014)

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms
por: Lai, Ying, et al.
Publicado: (2014)

Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain
por: Vardar, Gülçin, et al.
Publicado: (2022)

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission
por: Zarebidaki, Fereshteh, et al.
Publicado: (2020)

Synaptotagmin rings as high-sensitivity regulators of synaptic vesicle docking and fusion
por: Zhu, Jie, et al.
Publicado: (2022)

Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
por: Courtney, Nicholas A., et al.
Publicado: (2019)

Clathrin regenerates synaptic vesicles from endosomes
por: Watanabe, Shigeki, et al.
Publicado: (2014)

Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses
por: Vardar, Gülçin, et al.
Publicado: (2021)

Uncoupling the roles of synaptotagmin I as a dual Ca(2+) sensor during endo- and exocytosis of synaptic vesicles
por: Yao, Jun, et al.
Publicado: (2011)

Synaptotagmin 1 and Ca(2+) drive trans SNARE zippering
por: Lai, Ying, et al.
Publicado: (2014)

Differential Roles for Snapin and Synaptotagmin in the Synaptic Vesicle Cycle
por: Yu, Szi-Chieh, et al.
Publicado: (2013)

Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1
por: Huson, Vincent, et al.
Publicado: (2020)

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca(2+)
por: Chicka, Michael C, et al.
Publicado: (2008)

Synaptotagmin C2B Domain Regulates Ca(2+)-triggered Fusion in Vitro: CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS
por: Gaffaney, Jon D., et al.
Publicado: (2008)

A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion
por: Guan, Zhuo, et al.
Publicado: (2017)

Synaptotagmin-7 links fusion-activated Ca(2+) entry and fusion pore dilation
por: Neuland, Kathrin, et al.
Publicado: (2014)

The Janus-Faced Nature of the C(2)B Domain Is Fundamental for Synaptotagmin-1 Function
por: Xue, Mingshan, et al.
Publicado: (2008)

Structural basis for the clamping and Ca(2+) activation of SNARE-mediated fusion by synaptotagmin
por: Grushin, Kirill, et al.
Publicado: (2019)

Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesicles
por: Kaempf, Natalie, et al.
Publicado: (2015)

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion
por: Wang, Zhao, et al.
Publicado: (2011)

Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice
por: Hoffmann-Conaway, Sheila, et al.
Publicado: (2020)

Synaptotagmin II Negatively Regulates Ca(2+)-triggered Exocytosis of Lysosomes in Mast Cells
por: Baram, Dana, et al.
Publicado: (1999)

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
por: Maximov, Anton, et al.
Publicado: (2007)

The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease
por: Öhrfelt, Annika, et al.
Publicado: (2016)

The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts
Publicado: (1993)

Glycosylation Is Dispensable for Sorting of Synaptotagmin 1 but Is Critical for Targeting of SV2 and Synaptophysin to Recycling Synaptic Vesicles
por: Kwon, Sung E., et al.
Publicado: (2012)

Calcium/synaptotagmin-evoked compound fusion increases quantal size and synaptic strength
por: He, Liming, et al.
Publicado: (2009)

Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology
por: Fenske, Pascal, et al.
Publicado: (2019)

Productive and Non-productive Pathways for Synaptotagmin 1 to Support Ca(2+)-Triggered Fast Exocytosis
por: Kim, Jaewook, et al.
Publicado: (2017)

The tandem C2 domains of synaptotagmin contain redundant Ca(2)+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis
por: Earles, Cynthia A., et al.
Publicado: (2001)

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)

Synaptotagmin oligomers are necessary and can be sufficient to form a Ca(2+)‐sensitive fusion clamp
por: Ramakrishnan, Sathish, et al.
Publicado: (2019)

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity
por: Shimojo, Masafumi, et al.
Publicado: (2019)

Enhanced synaptotagmin plasticity derived from pairing intrinsic disorder with synaptic vesicle lipids
por: Fealey, Michael E., et al.
Publicado: (2017)

Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains
por: Barber, Cynthia F., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jtvgajkm0pm9dok83lhtqf4kab