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IL-2/IL-15 activate the human clonally-restricted KIR3DL1 reverse promoter

Killer cell immunoglobulin-like receptors (KIR) are expressed in a clonally-restricted fashion by human natural killer (NK) cells and allow detection of aberrant cells with low MHC class I levels. Clonally-restricted KIR transcription is maintained by demethylation of the proximal promoter. Antisens...

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Detalles Bibliográficos
Autores principales: Presnell, Steven R., Chan, Huei-Wei, Zhang, Lei, Lutz, Charles T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742563/
https://www.ncbi.nlm.nih.gov/pubmed/23328843
http://dx.doi.org/10.1038/gene.2012.62