Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

In multiple sclerosis (MS), activated microglia and infiltrating macrophages phagocytose myelin focally in (chronic) active lesions. These demyelinating sites expand in time, but at some point turn inactive into a sclerotic scar. To identify molecular mechanisms underlying lesion activity and halt,...

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Detalles Bibliográficos
Autores principales: Hendrickx, Debbie A. E., van Scheppingen, Jackelien, van der Poel, Marlijn, Bossers, Koen, Schuurman, Karianne G., van Eden, Corbert G., Hol, Elly M., Hamann, Jörg, Huitinga, Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742619/
https://www.ncbi.nlm.nih.gov/pubmed/29312322
http://dx.doi.org/10.3389/fimmu.2017.01810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742619/
https://www.ncbi.nlm.nih.gov/pubmed/29312322
http://dx.doi.org/10.3389/fimmu.2017.01810

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