Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer

Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3–7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved small molecule inhibitors targeting ALK fusio...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Haderk, Franziska, Bivona, Trever G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742812/
https://www.ncbi.nlm.nih.gov/pubmed/29189709
http://dx.doi.org/10.3390/cancers9120164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742812/
https://www.ncbi.nlm.nih.gov/pubmed/29189709
http://dx.doi.org/10.3390/cancers9120164

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