Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane

The mechanistic target of rapamycin (mTOR) signal-transduction pathway plays a key role in regulating many aspects of metabolic processes. The central player of the mTOR signaling pathway, mTOR complex 1 (mTORC1), is recruited by the pentameric Ragulator complex and the heterodimeric Rag GTPase comp...

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Detalles Bibliográficos
Autores principales: Mu, Zongkai, Wang, Lei, Deng, Wei, Wang, Jiawei, Wu, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742854/
https://www.ncbi.nlm.nih.gov/pubmed/29285400
http://dx.doi.org/10.1038/celldisc.2017.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742854/
https://www.ncbi.nlm.nih.gov/pubmed/29285400
http://dx.doi.org/10.1038/celldisc.2017.49

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