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Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities

Conventional class B cytosine-guanine (CpG) (CpG-B) oligodeoxynucleotide (ODNs) consisting of a single-stranded (ss) phosphorothioate (PT) backbone (ss CpG-B-PT) is converted from a proinflammatory cytokine inducer to a type-I interferon (IFN) inducer when complexed with cationic materials. In this...

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Detalles Bibliográficos
Autores principales:	Hanagata, Nobutaka, Li, Xianglan, Chen, Min-Hua, Li, Jie, Hattori, Shinya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743182/ https://www.ncbi.nlm.nih.gov/pubmed/29317815 http://dx.doi.org/10.2147/IJN.S152141

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