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Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation
Th17 cells are critically involved in host defense, inflammation, and autoimmunity(1–5). TGF-β is instrumental in Th17 differentiation by cooperating with IL-6(6,7). Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743442/ https://www.ncbi.nlm.nih.gov/pubmed/29072299 http://dx.doi.org/10.1038/nature24283 |