Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation

Th17 cells are critically involved in host defense, inflammation, and autoimmunity(1–5). TGF-β is instrumental in Th17 differentiation by cooperating with IL-6(6,7). Yet, the mechanism of how TGF-β enables Th17 differentiation remains elusive. Here we reveal that TGF-β licenses Th17 differentiation...

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Detalles Bibliográficos
Autores principales: Zhang, Song, Takaku, Motoki, Zou, Liyun, Gu, Ai-di, Chou, Wei-chun, Zhang, Ge, Wu, Bing, Kong, Qing, Thomas, Seddon Y., Serody, Jonathan S., Chen, Xian, Xu, Xiaojiang, Wade, Paul A., Cook, Donald N., Ting, Jenny P., Wan, Yisong Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743442/
https://www.ncbi.nlm.nih.gov/pubmed/29072299
http://dx.doi.org/10.1038/nature24283

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