Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice

BACKGROUND: The potential carcinogenicity of naphthalene (NA), a ubiquitous environmental pollutant, in human respiratory tract is a subject of intense debate. Chief among the uncertainties in risk assessment for NA is whether human lung CYP2A13 and CYP2F1 can mediate NA’s respiratory tract toxicity...

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Detalles Bibliográficos
Autores principales: Li, Lei, Carratt, Sarah, Hartog, Matthew, Kovalchuk, Nataliia, Jia, Kunzhi, Wang, Yanan, Zhang, Qing-Yu, Edwards, Patricia, Van Winkle, Laura, Ding, Xinxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Environmental Health Perspectives 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743450/
https://www.ncbi.nlm.nih.gov/pubmed/28599267
http://dx.doi.org/10.1289/EHP844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743450/
https://www.ncbi.nlm.nih.gov/pubmed/28599267
http://dx.doi.org/10.1289/EHP844

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