Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas

Rationale: Oncogenic STAT3 signaling activation and 3p22-21.3 locus alteration are common in multiple tumors, especially carcinomas of the nasopharynx, esophagus and lung. Whether these two events are linked remains unclear. Our CpG methylome analysis identified a 3p22.2 gene, DLEC1, as a methylated...

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Detalles Bibliográficos
Autores principales: Li, Lili, Xu, Juan, Qiu, Guohua, Ying, Jianming, Du, Zhenfang, Xiang, Tingxiu, Wong, Kai Yau, Srivastava, Gopesh, Zhu, Xiao-Feng, Mok, Tony S, Chan, Anthony TC, Chan, Francis KL, Ambinder, Richard F, Tao, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743460/
https://www.ncbi.nlm.nih.gov/pubmed/29290793
http://dx.doi.org/10.7150/thno.20893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743460/
https://www.ncbi.nlm.nih.gov/pubmed/29290793
http://dx.doi.org/10.7150/thno.20893

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