Cargando…

Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK/ERK pathways

Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Kangmei, Liu, Michelle Xin, Mak, Celia Sze-Ling, Yung, Mingo Ming-Ho, Leung, Thomas Ho-Yin, Xu, Dakang, Ngu, Siew-Fei, Chan, Karen Kar-Loen, Yang, Huijuan, Ngan, Hextan Yuen-Sheung, Chan, David Wai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743558/ https://www.ncbi.nlm.nih.gov/pubmed/29290818 http://dx.doi.org/10.7150/thno.22377

Ejemplares similares

GRO-α and IL-8 enhance ovarian cancer metastatic potential via the CXCR2-mediated TAK1/NFκB signaling cascade
por: Yung, Mingo Ming-Ho, et al.
Publicado: (2018)

Tamoxifen use in recurrent ovarian cancer in a Chinese population: A 15 ‐year clinical experience in a tertiary referral center
por: Chan, Karen Kar Loen, et al.
Publicado: (2020)

Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells
por: Chan, David W., et al.
Publicado: (2012)

The Value of Four-Quadrant Cervical Biopsy in Women with Different Colposcopic Impressions
por: Chu, Mandy Man-Yee, et al.
Publicado: (2023)

Role of Nurr1 in Carcinogenesis and Tumor Immunology: A State of the Art Review
por: Wan, Peter Kok-Ting, et al.
Publicado: (2020)

Germline mutations in Chinese ovarian cancer with or without breast cancer
por: Kwong, Ava, et al.
Publicado: (2022)

Differentiation of aggressive and indolent subtypes of uterine sarcoma using maximum standardized uptake value
por: Lee, Elaine Yuen Phin, et al.
Publicado: (2013)

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
por: Yung, Mingo Ming Ho, et al.
Publicado: (2013)

A Combination of Glutaminase Inhibitor 968 and PD-L1 Blockade Boosts the Immune Response against Ovarian Cancer
por: Wang, Jing-Jing, et al.
Publicado: (2021)

A patient with relapsed high-grade serous ovarian carcinoma with somatic RAD51C mutations treated with PARPi monotherapy: a case report
por: Ngu, Siew-Fei, et al.
Publicado: (2022)

Combined electroacupuncture and auricular acupuncture for postoperative pain after abdominal surgery for gynecological diseases: study protocol for a randomized controlled trial
por: Lam, Wing Lok, et al.
Publicado: (2018)

Ascites-derived ALDH+CD44+ tumour cell subsets endow stemness, metastasis and metabolic switch via PDK4-mediated STAT3/AKT/NF-κB/IL-8 signalling in ovarian cancer
por: Jiang, Yu-Xin, et al.
Publicado: (2020)

Surgery including fertility-sparing treatment of GTD
por: Ngu, Siew-Fei, et al.
Publicado: (2021)

Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells
por: Chen, Rain R., et al.
Publicado: (2019)

CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma
por: Mo, Xue-Tang, et al.
Publicado: (2020)

Prevalence and Risk Factors of Human Papillomavirus (HPV) Infection in Southern Chinese Women – A Population-Based Study
por: Liu, Stephanie Si, et al.
Publicado: (2011)

TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells
por: Zhang, Pingde, et al.
Publicado: (2012)

MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
por: Mak, Celia S. L., et al.
Publicado: (2017)

Epigenetic Silencing of miR-33b Promotes Peritoneal Metastases of Ovarian Cancer by Modulating the TAK1/FASN/CPT1A/NF-κB Axis
por: Wang, Xueyu, et al.
Publicado: (2021)

The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression
por: Wang, Huogang, et al.
Publicado: (2021)

The Macronova in GRB 050709 and the GRB-macronova connection
por: Jin, Zhi-Ping, et al.
Publicado: (2016)

Orchestrated Action of AMPK Activation and Combined VEGF/PD-1 Blockade with Lipid Metabolic Tunning as Multi-Target Therapeutics against Ovarian Cancers
por: Yung, Mingo M. H., et al.
Publicado: (2022)

Evaluation of an Isothermal Amplification HPV Assay on Self-Collected Vaginal Samples as Compared to Clinician-Collected Cervical Samples
por: Chan, Aaron H. Y., et al.
Publicado: (2023)

Epigenetically altered miR-193a-3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7
por: Tang, Yiyin, et al.
Publicado: (2019)

Human Papillomavirus Self-Sampling for Primary Cervical Cancer Screening in Under-Screened Women in Hong Kong during the COVID-19 Pandemic
por: Ngu, Siew-Fei, et al.
Publicado: (2022)

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment
por: Liang, Rui, et al.
Publicado: (2021)

Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
por: Mo, Yulan, et al.
Publicado: (2023)

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1
por: Qu, Yingying, et al.
Publicado: (2014)

Down-regulation of Sox7 is associated with aberrant activation of Wnt/β-catenin signaling in endometrial cancer
por: Chan, David W, et al.
Publicado: (2012)

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases
por: Zhan, Shijie, et al.
Publicado: (2022)

Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer
por: Liu, Michelle X., et al.
Publicado: (2013)

Treatment Outcomes of Computer Tomography-Guided Brachytherapy in Cervical Cancer in Hong Kong: A Retrospective Review
por: Chan, Wing-Lok, et al.
Publicado: (2022)

Patient-Initiated Follow-Up in Ovarian Cancer
por: Luk, Hiu Mei, et al.
Publicado: (2023)

SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells
por: Xuan, Yang, et al.
Publicado: (2022)

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells
por: Lok, Gabriel T. M., et al.
Publicado: (2011)

PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling
por: Siu, Michelle K. Y., et al.
Publicado: (2020)

Association between High Diffusion-Weighted Imaging-Derived Functional Tumor Burden of Peritoneal Carcinomatosis and Overall Survival in Patients with Advanced Ovarian Carcinoma
por: An, He, et al.
Publicado: (2022)

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
por: Yung, Mingo M. H., et al.
Publicado: (2015)

Correction: Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells
Publicado: (2014)

COMPTEL analysis of GRB 940217
por: Winkler, C M, et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_3euc4711gnk9o96v4rqq76bgkm