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Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma

Ethnopharmacological relevance: Dapivirine is one of reverse transcriptase inhibitors (RTIs). It is the prototype of diarylpyrimidines (DAPY), formerly known as TMC120 or DAPY R147681 (IUPAC name: 4- [[4-(2, 4, 6-trimethylphenyl) amino]-2-pyrimidinyl] amino]-benzonitrile; CAS no.244767-67-7). Aim: T...

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Detalles Bibliográficos
Autores principales: Liu, Weiwen, Song, Xian-lu, Zhao, Shan-chao, He, Minyi, Wang, Hai, Chen, Ziyang, Xiang, Wei, Yi, Guozhong, Qi, Songtao, Liu, Yawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743718/
https://www.ncbi.nlm.nih.gov/pubmed/29290776
http://dx.doi.org/10.7150/jca.21965