Cargando…

Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma

PURPOSE: Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these adenocarcinomas is essential. The dysregulation of the oncoprotein, PKB/Akt has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miles, James, Applebee, Christopher J., Leboucher, Pierre, Lopez-Fernandez, Sonia, Lee, Dae-Jin, Guarch, Rosa, Ward, Stephen, Parker, Peter J., López, Jose I., Larijani, Banafshé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744020/ https://www.ncbi.nlm.nih.gov/pubmed/29296589 http://dx.doi.org/10.1016/j.bbacli.2017.10.002

Ejemplares similares

Dynamics of PLCγ and Src Family Kinase 1 Interactions during Nuclear Envelope Formation Revealed by FRET-FLIM
por: Byrne, Richard D., et al.
Publicado: (2012)

HER2 Oncogenic Function Escapes EGFR Tyrosine Kinase Inhibitors via Activation of Alternative HER Receptors in Breast Cancer Cells
por: Kong, Anthony, et al.
Publicado: (2008)

Quantification of biomarker functionality predicts patient outcomes
por: Larijani, Banafshé, et al.
Publicado: (2021)

Snail heterogeneity in clear cell renal cell carcinoma
por: Zaldumbide, Laura, et al.
Publicado: (2016)

The unprecedented membrane deformation of the human nuclear envelope, in a magnetic field, indicates formation of nuclear membrane invaginations
por: Dazzoni, Régine, et al.
Publicado: (2020)

Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC)
por: Guarch, Rosa, et al.
Publicado: (2016)

Tumor-to-Tumor Metastases Involving Clear Cell Renal Cell Carcinomas: A Diagnostic Challenge for Pathologists Needing Clinical Correlation †
por: Manini, Claudia, et al.
Publicado: (2023)

Typing of a Polymorphic Human Gene Conferring Susceptibility to Insulin-Dependent Diabetes Mellitus by Picosecond-Resolved FRET on Non-Purified/Non-Amplified Genomic DNA
por: Nardo, Luca, et al.
Publicado: (2012)

Single molecule FRET observation of kinesin-1’s head-tail interaction on microtubule
por: Aoki, Takahiro, et al.
Publicado: (2013)

Measuring conformational equilibria in allosteric proteins with time-resolved tmFRET
por: Zagotta, William N., et al.
Publicado: (2023)

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation
por: Sakakura, C, et al.
Publicado: (2001)

Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer
por: Falcón, O, et al.
Publicado: (1999)

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET
por: Qiu, Xue, et al.
Publicado: (2018)

ASNS can predict the poor prognosis of clear cell renal cell carcinoma
por: Gan, Xinqiang, et al.
Publicado: (2022)

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET
por: Moss, Fraser J., et al.
Publicado: (2009)

Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET
por: Jeng, Sunny C.Y., et al.
Publicado: (2021)

FRET‐Integrated Polymer Brushes for Spatially Resolved Sensing of Changes in Polymer Conformation
por: Besford, Quinn A., et al.
Publicado: (2021)

Resolving the Delusion Paradox
por: Petrovic, Predrag, et al.
Publicado: (2023)

Co-expression network analysis identified six hub genes in association with progression and prognosis in human clear cell renal cell carcinoma (ccRCC)
por: Yuan, Lushun, et al.
Publicado: (2017)

State transitions and photosystems spatially resolved in individual cells of the cyanobacterium Synechococcus elongatus
por: Bhatti, Ahmad Farhan, et al.
Publicado: (2021)

BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues
por: Cottet, Martin, et al.
Publicado: (2012)

p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung
por: Huang, C-I, et al.
Publicado: (2000)

The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
por: Errarte, Peio, et al.
Publicado: (2016)

Rab25 expression predicts poor prognosis in clear cell renal cell carcinoma
por: LIU, LUNZHI, et al.
Publicado: (2014)

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma
por: Xiao, Wen, et al.
Publicado: (2019)

Overexpression of IRF3 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
por: Wu, Jun, et al.
Publicado: (2021)

Decreased Expression of ACADSB Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma
por: Liu, Xianhui, et al.
Publicado: (2022)

Hemoglobin β Expression Is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma
por: Kurota, Yuta, et al.
Publicado: (2023)

Met Is the Most Frequently Amplified Gene in Endometriosis-Associated Ovarian Clear Cell Adenocarcinoma and Correlates with Worsened Prognosis
por: Yamashita, Yoriko, et al.
Publicado: (2013)

Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer
por: Keum, J S, et al.
Publicado: (1999)

Time-Resolved FRET -Based Approach for Antibody Detection – A New Serodiagnostic Concept
por: Saraheimo, Satu, et al.
Publicado: (2013)

Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy
por: Blacker, Thomas S., et al.
Publicado: (2016)

Resolving distance variations by single-molecule FRET and EPR spectroscopy using rotamer libraries
por: Klose, Daniel, et al.
Publicado: (2021)

Rho GTPase isoforms in cell motility: Don't fret, we have FRET
por: Donnelly, Sara K, et al.
Publicado: (2014)

QuanTI-FRET: a framework for quantitative FRET measurements in living cells
por: Coullomb, Alexis, et al.
Publicado: (2020)

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
por: Calleja, Véronique, et al.
Publicado: (2009)

Photocaged amplified FRET nanoflares: spatiotemporal controllable of mRNA-powered nanomachines for precise and sensitive microRNA imaging in live cells
por: Li, Jing, et al.
Publicado: (2021)

High expression of FUT3 is linked to poor prognosis in clear cell renal cell carcinoma
por: Meng, Li, et al.
Publicado: (2017)

Increased expression of RUNX1 in clear cell renal cell carcinoma predicts poor prognosis
por: Fu, Yang, et al.
Publicado: (2019)

Decreased expression of TXNIP predicts poor prognosis in patients with clear cell renal cell carcinoma
por: Gao, Yuan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s8h5jijs5big6o524ne9mcdllt