Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector

Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway for regulating energy balance—is brain-derived neurotr...

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Detalles Bibliográficos
Autores principales: Siu, Jason J., Queen, Nicholas J., Liu, Xianglan, Huang, Wei, McMurphy, Travis, Cao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744069/
https://www.ncbi.nlm.nih.gov/pubmed/29296625
http://dx.doi.org/10.1016/j.omtm.2017.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744069/
https://www.ncbi.nlm.nih.gov/pubmed/29296625
http://dx.doi.org/10.1016/j.omtm.2017.09.005

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