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Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Mutations in the melanocortin-4-receptor (MC4R) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either ineffective long-term or contraindicated. Immediately downstream of MC4R—in the pathway for regulating energy balance—is brain-derived neurotr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744069/ https://www.ncbi.nlm.nih.gov/pubmed/29296625 http://dx.doi.org/10.1016/j.omtm.2017.09.005 |