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Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis?

Cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins secreted by Gram-positive bacteria. These toxins form transmembrane pores by inserting a large β-barrel into cholesterol-containing membranes. Cholesterol is absolutely required for pore-formation. For most CDCs, bind...

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Detalles Bibliográficos
Autores principales:	Savinov, Sergey N., Heuck, Alejandro P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744101/ https://www.ncbi.nlm.nih.gov/pubmed/29168745 http://dx.doi.org/10.3390/toxins9120381

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