Cargando…

Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7

The depressant β toxin anti-neuroexcitation peptide (ANEP) from the Chinese scorpion Buthus martensii Karsch has analgesic activity by interacting with receptor site 4 of the voltage-gated sodium channels (VGSCs). Here, with molecular dynamics simulations, we examined the binding modes between ANEP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yongbo, Liu, Zeyu, Zhang, Qi, Li, Chunming, Jin, Wei, Liu, Lili, Zhang, Jianye, Zhang, Jinghai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744107/ https://www.ncbi.nlm.nih.gov/pubmed/29186022 http://dx.doi.org/10.3390/toxins9120387

Ejemplares similares

CDNA Cloning, Heterologous Expression and Characterization of Anti-Neuroexcitation Peptides (ANEPS) of Scorpion Buthus martensii Karsch
por: Zhang, Jing-Hai, et al.
Publicado: (2001)

Interaction of Scorpion α-Toxins with Cardiac Sodium Channels: Binding Properties and Enhancement of Slow Inactivation
por: Chen, Haijun, et al.
Publicado: (2001)

The scorpion toxin and the potassium channel
por: Swartz, Kenton J
Publicado: (2013)

Binding of scorpion toxin to receptor sites associated with sodium channels in frog muscle. Correlation of voltage-dependent binding with activation
Publicado: (1979)

Scorpion model of influenza A/H1N1: Hemagglutinin (HA) contains a scorpion toxin, binding to voltage-gated sodium Na+ channel: Na+ channel inhibitors as therapy
por: Tran, Guy Mong Ky, et al.
Publicado: (2010)

Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics
por: Chen, Rong, et al.
Publicado: (2014)

β-Scorpion Toxin Modifies Gating Transitions in All Four Voltage Sensors of the Sodium Channel
por: Campos, Fabiana V., et al.
Publicado: (2007)

Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
por: Jiang, Daohua, et al.
Publicado: (2021)

Allosteric interactions among voltage-sensor modules of sodium channels probed by scorpion toxin modifiers
por: Gurevitz, Michael, et al.
Publicado: (2022)

Structural and Functional Diversity of Acidic Scorpion Potassium Channel Toxins
por: Chen, Zong-Yun, et al.
Publicado: (2012)

α-Scorpion Toxin Impairs a Conformational Change that Leads to Fast Inactivation of Muscle Sodium Channels
por: Campos, Fabiana V., et al.
Publicado: (2008)

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom
por: Martin-Eauclaire, Marie-France, et al.
Publicado: (2019)

Study of Anti-Inflammatory and Analgesic Activity of Scorpion Toxins DKK-SP1/2 from Scorpion Buthus martensii Karsch (BmK)
por: Liu, Yunxia, et al.
Publicado: (2021)

Scorpion β-toxin interference with Na(V) channel voltage sensor gives rise to excitatory and depressant modes
por: Leipold, Enrico, et al.
Publicado: (2012)

Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy
por: Dueñas-Cuellar, Rosa Amalia, et al.
Publicado: (2020)

Target-Driven Evolution of Scorpion Toxins
por: Zhang, Shangfei, et al.
Publicado: (2015)

Direct Evidence that Scorpion α-Toxins (Site-3) Modulate Sodium Channel Inactivation by Hindrance of Voltage-Sensor Movements
por: Ma, Zhongming, et al.
Publicado: (2013)

Kalium: a database of potassium channel toxins from scorpion venom
por: Kuzmenkov, Alexey I., et al.
Publicado: (2016)

Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression
por: Oliveira, Isadora S, et al.
Publicado: (2019)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus
Publicado: (1989)

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes
por: Zhao, Yonghui, et al.
Publicado: (2019)

Shellfish Toxins Targeting Voltage-Gated Sodium Channels
por: Zhang, Fan, et al.
Publicado: (2013)

Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin
por: Cestèle, Sandrine, et al.
Publicado: (2001)

General mechanism of spider toxin family I acting on sodium channel Nav1.7
por: Yuan, Fu-Chu, et al.
Publicado: (2022)

Scorpion Toxins Specific for Potassium (K(+)) Channels: A Historical Overview of Peptide Bioengineering
por: Bergeron, Zachary L., et al.
Publicado: (2012)

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
por: Hakim, Md Abdul, et al.
Publicado: (2015)

Recombinant scorpion toxins: Focus on four-disulfide peptide blockers of Kv1-channels
por: Nekrasova, Oksana, et al.
Publicado: (2017)

Pain-related toxins in scorpion and spider venoms: a face to face with ion channels
por: Diochot, Sylvie
Publicado: (2021)

Overview of Scorpion Species from China and Their Toxins
por: Cao, Zhijian, et al.
Publicado: (2014)

Fluorescent protein-scorpion toxin chimera is a convenient molecular tool for studies of potassium channels
por: Kuzmenkov, Alexey I., et al.
Publicado: (2016)

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)
por: Yang, Daryl C., et al.
Publicado: (2016)

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating
Publicado: (1981)

Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na(+)-Channel Scorpion Toxins
por: Guerrero-Vargas, Jimmy A., et al.
Publicado: (2012)

Hadrurid Scorpion Toxins: Evolutionary Conservation and Selective Pressures
por: Santibáñez-López, Carlos E., et al.
Publicado: (2019)

A bimodal activation mechanism underlies scorpion toxin–induced pain
por: Yang, Shilong, et al.
Publicado: (2017)

Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin
por: Zhang, Shangfei, et al.
Publicado: (2018)

Rapid voltage-dependent dissociation of scorpion alpha-toxins coupled to Na channel inactivation in amphibian myelinated nerves
Publicado: (1986)

Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
por: Hu, You-Tian, et al.
Publicado: (2014)

Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
por: Haji-Ghassemi, Omid, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i4pifmhifskfdhtjsu1gdavsl4