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Systems Pharmacology of VEGF165b in Peripheral Artery Disease

We built a whole‐body computational model to study the role of the poorly understood vascular endothelial growth factor (VEGF)(165b) splice isoform in peripheral artery disease (PAD). This model was built and validated using published and new experimental data from cells, mice, and humans, and expli...

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Detalles Bibliográficos
Autores principales: Clegg, Lindsay E., Ganta, Vijay C., Annex, Brian H., Mac Gabhann, Feilim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744173/
https://www.ncbi.nlm.nih.gov/pubmed/29193887
http://dx.doi.org/10.1002/psp4.12261