Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

[Image: see text] The C-19 quassinoid eurycomalactone (1) has recently been shown to be a potent (IC(50) = 0.5 μM) NF-κB inhibitor in a luciferase reporter model. In this study, we show that 1 with similar potency inhibited the expression of the NF-κB-dependent target genes ICAM-1, VCAM-1, and E-sel...

Descripción completa

Detalles Bibliográficos
Autores principales: Malainer, Clemens, Schachner, Daniel, Sangiovanni, Enrico, Atanasov, Atanas G., Schwaiger, Stefan, Stuppner, Hermann, Heiss, Elke H., Dirsch, Verena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744186/
https://www.ncbi.nlm.nih.gov/pubmed/29148754
http://dx.doi.org/10.1021/acs.jnatprod.7b00503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744186/
https://www.ncbi.nlm.nih.gov/pubmed/29148754
http://dx.doi.org/10.1021/acs.jnatprod.7b00503

Ejemplares similares