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Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level
[Image: see text] The C-19 quassinoid eurycomalactone (1) has recently been shown to be a potent (IC(50) = 0.5 μM) NF-κB inhibitor in a luciferase reporter model. In this study, we show that 1 with similar potency inhibited the expression of the NF-κB-dependent target genes ICAM-1, VCAM-1, and E-sel...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744186/ https://www.ncbi.nlm.nih.gov/pubmed/29148754 http://dx.doi.org/10.1021/acs.jnatprod.7b00503 |