The Ubiquitination of PINK1 Is Restricted to Its Mature 52-kDa Form

Along with Parkin, PINK1 plays a critical role in maintaining mitochondrial quality control. Although PINK1 is expressed constitutively, its level is kept low in healthy mitochondria by polyubiquitination and ensuing proteasomal degradation of its mature, 52 kDa, form. We show here that the target o...

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Detalles Bibliográficos
Autores principales: Liu, Yuhui, Guardia-Laguarta, Cristina, Yin, Jiang, Erdjument-Bromage, Hediye, Martin, Brittany, James, Michael, Jiang, Xuejun, Przedborski, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745057/
https://www.ncbi.nlm.nih.gov/pubmed/28683321
http://dx.doi.org/10.1016/j.celrep.2017.06.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745057/
https://www.ncbi.nlm.nih.gov/pubmed/28683321
http://dx.doi.org/10.1016/j.celrep.2017.06.022

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