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Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

Vertebrate embryonic patterning depends on signaling from Nodal, a TGFβ superfamily member. There are three Nodal orthologs in zebrafish; southpaw directs left-right asymmetries, while squint and cyclops function earlier to pattern mesendoderm. TGFβ member Vg1 is implicated in mesoderm formation but...

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Detalles Bibliográficos
Autores principales: Pelliccia, Jose L, Jindal, Granton A, Burdine, Rebecca D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745080/
https://www.ncbi.nlm.nih.gov/pubmed/29140250
http://dx.doi.org/10.7554/eLife.28635