Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes

In order to replace the use of animals in toxicity testing, there is a need to predict human in vivo toxic doses from concentrations that cause adverse effects in in vitro test systems. The virtual cell based assay (VCBA) has been developed to simulate intracellular concentrations as a function of t...

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Detalles Bibliográficos
Autores principales: Worth, Andrew P., Louisse, Jochem, Macko, Peter, Sala Benito, J.V., Paini, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745147/
https://www.ncbi.nlm.nih.gov/pubmed/28911986
http://dx.doi.org/10.1016/j.tiv.2017.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745147/
https://www.ncbi.nlm.nih.gov/pubmed/28911986
http://dx.doi.org/10.1016/j.tiv.2017.09.009

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