Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism remains unclear. Here, we establish a dual role...

Descripción completa

Detalles Bibliográficos
Autores principales: Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745148/
https://www.ncbi.nlm.nih.gov/pubmed/29220652
http://dx.doi.org/10.1016/j.molcel.2017.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745148/
https://www.ncbi.nlm.nih.gov/pubmed/29220652
http://dx.doi.org/10.1016/j.molcel.2017.10.017

Ejemplares similares